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KMID : 0363120080210010033
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Korean Journal of Pain
2008 Volume.21 No. 1 p.33 ~ p.37
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Superior Cervical Sympathetic Ganglion Block may not Influence Early Brain Damage Induced by Permanent Focal Cerebral Ischemia in Rats
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Kim Hyun-Hae
Leem Jeong-Gill
Shin Jin-Woo
Sim Ji-Yeon
Lee Dong-Myung
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Abstract
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Background: Cerebral blood vessels are innervated by sympathetic nerves from the superior cervical ganglion
(SCG). The purpose of the present study was to evaluate the neuroprotective effect of superior cervical sympathetic
ganglion block in rats subjected to permanent focal cerebral ischemia.
Methods: Thirty male Sprague-Dawley rats (270?320 g) were randomly assigned to one of three groups
(control, lidocaine and ropivacaine). A brain injury was induced in all rats by middle cerebral artery occlusion
with a nylon thread. The animals of the local anesthetic group received 30μl of 2% lidocaine or 0.75%
ropivacaine in the SCG. Neurologic scores were assessed 24 hours after brain injury. Brain samples were then
collected. The infarct and edema ratios were measured by 2.3.5-triphenyltetrazolium chloride staining.
Results: There were no differences in the death rates, neurologic scores, or infarction and edema ratios
between the three groups.
Conclusions: These findings suggest that superior cervical sympathetic ganglion block may not influence
the brain damage induced by permanent focal cerebral ischemia in rats. (Korean J Pain 2008; 21: 33?37)
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KEYWORD
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cervical sympathetic ganglion block, focal cerebral ischemia, rat
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